We overview the state of the art in the field of safe exposure levels setting for nanomaterials together with the previously published\r\nresults of our experimental investigations characterizing comparative toxicity of the iron oxide Fe3O4 (magnetite) in the form of\r\nmicroparticles and nanoparticles of different size and comparative activity of the defensive alveolar phagocytosis response to their\r\npulmonary deposition. An approach to the substantiation of acceptable workplace exposure limits of metallic nanoparticles is\r\ndiscussed and, specifically, the tentative reference level for magnetite nanoparticles is recommended.
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